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056. Bone metabolism

visual-inline rebuild1 extracted figuresspeaker notes XML24 study lines1 Q&A

Individual slide images have been cropped from the rendered slide and inserted beside the matching note section. The full slide remains below only for layout/audit.

Clean FRCS notes with inline figures

Bone metabolism

Radiograph / imaging — Fig 1. Radiograph / imagingtop left

•Controlled by 3 hormone

•PTH

•Vit D

•Calcitonin

•Others: GH, estrogen, steroid, T4

•Produced by skin with UV light exposure

•7-dehydrocholesterol → cholecalciferol

•Metabolized in liver and then kidney

•→ 25 hydroxy Vit D → 1 25 hydroxy Vit D

•Action

•GI

•Absorb Ca

•Absorb PO4

•2. Bone

•Activate osteoblast matrix production

•Increased osteoclast action through RANK-RANKL

•3. Inhibit PTH

•UP Regulation of Vit D3

•Increased PTH (hydroxylation in kidney)

•Low Calcium level, low PO4 level

•Decreased Vit D3 (auto-regulation)

•Calcidiol = 25 hydroxy vit D

•Calcitriol = 1 25 hydroxy vit D

Direct Q&A

Q1 What are the diagnostic findings and management points for Bone metabolism?

Bone metabolism

•Controlled by 3 hormone

•PTH

•Vit D

•Calcitonin

•Others: GH, estrogen, steroid, T4

•Produced by skin with UV light exposure

•7-dehydrocholesterol → cholecalciferol

•Metabolized in liver and then kidney

•→ 25 hydroxy Vit D → 1 25 hydroxy Vit D

•Action

•GI

•Absorb Ca

•Absorb PO4

•2. Bone

•Activate osteoblast matrix production

•Increased osteoclast action through RANK-RANKL

•3. Inhibit PTH

•UP Regulation of Vit D3

•Increased PTH (hydroxylation in kidney)

•Low Calcium level, low PO4 level

•Decreased Vit D3 (auto-regulation)

•Calcidiol = 25 hydroxy vit D

•Calcitriol = 1 25 hydroxy vit D

Raw speaker-note hierarchy audit

#	lvl	marL	indent	logical	original note line
1	0	None	None	0	Bone metabolism
2	0	None	None	0	Controlled by 3 hormone
3	0	228600	-228600	1	PTH
4	0	228600	-228600	1	Vit D
5	0	228600	-228600	1	Calcitonin
6	0	0	0	0	Others: GH, estrogen, steroid, T4
7	0	None	None	0	Vit D
8	0	None	None	0	Produced by skin with UV light exposure
9	1	None	None	1	7-dehydrocholesterol -> cholecalciferol
10	0	None	None	0	Metabolized in liver and then kidney
11	1	None	None	1	-> 25 hydroxy Vit D -> 1 25 hydroxy Vit D
12	0	None	None	0	Action
13	0	228600	-228600	1	GI
14	0	171450	-171450	1	Absorb Ca
15	0	171450	-171450	1	Absorb PO4
16	0	0	0	0	2. Bone
17	0	171450	-171450	1	Activate osteoblast matrix production
18	0	171450	-171450	1	Increased osteoclast action through RANK-RANKL
19	0	0	0	0	3. Inhibit PTH
20	0	0	0	0	UP Regulation of Vit D3
21	0	228600	-228600	1	Increased PTH (hydroxylation in kidney)
22	0	228600	-228600	1	Low Calcium level, low PO4 level
23	0	228600	-228600	1	Decreased Vit D3 (auto-regulation)
24	0	0	0	0	Calcidiol = 25 hydroxy vit D
25	0	0	0	0	Calcitriol = 1 25 hydroxy vit D

Improved semantic hierarchy used for the study notes

#	semantic level	section?	rewritten line
1	0		Bone metabolism
2	1		Controlled by 3 hormone
3	1		PTH
4	1		Vit D
5	1		Calcitonin
6	1		Others: GH, estrogen, steroid, T4
7	1		Produced by skin with UV light exposure
8	1		7-dehydrocholesterol → cholecalciferol
9	1		Metabolized in liver and then kidney
10	1		→ 25 hydroxy Vit D → 1 25 hydroxy Vit D
11	1		Action
12	1		GI
13	1		Absorb Ca
14	1		Absorb PO4
15	1		2. Bone
16	1		Activate osteoblast matrix production
17	1		Increased osteoclast action through RANK-RANKL
18	1		3. Inhibit PTH
19	1		UP Regulation of Vit D3
20	1		Increased PTH (hydroxylation in kidney)
21	1		Low Calcium level, low PO4 level
22	1		Decreased Vit D3 (auto-regulation)
23	1		Calcidiol = 25 hydroxy vit D
24	1		Calcitriol = 1 25 hydroxy vit D

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